Emerging Health Areas
The gut microbiome is the most extensively studied and well-characterized ecosystem in the human body. However, increasing attention is being directed toward other microbiomes, including the vaginal microbiome, which is central to our Women’s Health platform, as well as the oral and skin microbiomes.
Clinical research has long demonstrated the benefits of probiotics for skin conditions like atopic dermatitis, largely through their immunomodulatory effects on gut epithelial cells. More recently, emerging evidence highlights the existence of the microbiota-gut-skin axis, which links functions performed by the gut microbiome (e.g., regulation of immune responses and inflammation, nutrient absorption), and skin health.
Similarly, studies on the oral microbiome emphasize the role of probiotics in managing conditions characterized by gum inflammation, such as gingivitis and periodontitis. These findings suggest broader implications for systemic inflammation and overall health, reinforcing the importance of microbiome-targeted interventions.
Selected Publications
- Blais, L., Auclair-Ouellet, N., Tremblay, A., & Binda, S. (2025). Effect of the Darolac® (Oralis SB®) probiotic formulation on oral health: A narrative review. Microorganisms, 13(2), 408. https://doi.org/10.3390/microorganisms13020408
- Kassem, O., Tremblay, A., Ghaly, M. S. W., Oula, M.-L., Bronner, S., & Binda, S. (2025). A subjective evaluation of the effects of a probiotic formulation on skin quality in young adult females: Open-label proof-of-concept study. International Journal of Probiotics and Prebiotics, 20, 1-9. https://doi.org/10.37290/ijpp2641-7197.20:1-9
- Zhao, W., Ji, L., Li, J., Liu, D., Yan, C., Zhang, C., Wang, X., Liu, Y., & Zheng, S. (2025). Mesaconate from Bacillus subtilis R0179 supernatant attenuates periodontitis by inhibiting Porphyromonas gingivalis in mice. Journal of Periodontal Research, 60, 617-627. https://doi.org/10.1111/jre.13363
- Zhao, W., Ji, L., Li, J., Liu, D., Zhang, C., Wang, X., Liu, Y., & Zheng, S. (2025). Inactivated Bacillus subtilis R0179 inhibits Porphyromonas gingivalis-Induced gingival inflammation via TLR2/NF-κB signaling in a murine model of periodontitis. Inflammation. https://doi.org/10.1007/s10753-025-02348-8
- Zhao, W., Ji, L., Li, J., Liu, D., Zhang, C., Wang, X., Liu, Y., & Zheng, S. (2025). Inactivated Bacillus subtilis R0179 Inhibits Porphyromonas Gingivalis-Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis. Inflammation. https://doi.org/10.1007/s10753-025-02348-8
- Boyapati, R., Peeta, J., Dhulipalla, R., Kolaparthy, L., Adurty, C., & Cheruvu, R. N. S. (2024). Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: A randomized controlled trial. Dental and Medical Problems, 61(2), 181-189. https://doi.org/10.17219/dmp/156425
- Elgun, T., & Merdan, Y. E. (2023). Effect of Motiflor AS probiotic for oral health on cell viability in human gingival fibroblasts and human dental pulp stem cells. Journal of Conservative Dentistry and Endodontics, 26(6), 621-626. https://doi.org/10.4103/jcde.Jcde_125_23
- Nogueira, M. B., Massaut, K. B., Vitola, H. R. S., Siqueira, M. F. F., da Silva, W. P., & Fiorentini Â, M. (2023). Antagonistic activity of Lactobacillus spp. and Bifidobacterium spp. against cariogenic Streptococcus mutans in vitro and viability when added to chewing gum during storage. Brazilian Journal of Microbiology, 54(3), 2197-2204. https://doi.org/10.1007/s42770-023-01021-2
- Gedam, K. Y., & Katre, A. N. (2022). Efficacy of probiotic, chlorhexidine, and sodium fluoride mouthrinses on Mutans Streptococci in 8-to 12-year-old children: A crossover randomized trial. Lifestyle Genomics, 15, 35-44. https://doi.org/10.1159/000519916
- Ranjith, A., Nazimudeen, N. B., & Baiju, K. V. (2022). Probiotic mouthwash as an adjunct to mechanical therapy in the treatment of stage II periodontitis: A randomized controlled clinical trial. International Journal of Dental Hygiene, 20(2), 415-421. https://doi.org/10.1111/idh.12589
- Doppalapudi, R., Vundavalli, S., & Prabhat, M. (2020). Effect of probiotic bacteria on oral Candida in head-and neck-radiotherapy patients: A randomized clinical trial. Journal of Cancer Research and Therapeutics, 16(3), 470-477. https://doi.org/10.4103/jcrt.JCRT_334_18
- Chernyshov, P. V. (2009). B7‐2/CD28 costimulatory pathway in children with atopic dermatitis and its connection with immunoglobulin E, intracellular interleukin‐4 and interferon‐gamma production by T cells during a 1‐month follow‐up. Journal of the European Academy of Dermatology and Venereology, 23(6), 656-659. https://doi.org/10.1111/j.1468-3083.2009.03133.x
- Chernyshov, P. V. (2009). Randomized, placebo-controlled trial on clinical and immunologic effects of probiotic containing Lactobacillus rhamnosus R0011 and L. helveticus R0052 in infants with atopic dermatitis. Microbial Ecology in Health and Disease, 21(3-4), 228-232. https://doi.org/10.3109/08910600903444234