Our research on the benefits of probiotics in metabolic health concern long-established areas of interest, such as the management of obesity, hypercholesterolemia, and other cardiovascular risk factors, but also novel and emerging areas, such as the promotion of muscle health in aging.  Our preclinical research, which uses state-of-the-art multiomics techniques and benefits from a fully integrated in-house Caenorhabditis elegans platform, helps us better understand the metabolic mechanisms that subtend the effects of our probiotics. As such, our research on metabolic health provides many essential insights to our research in other health areas, in addition to highlighting the relationships between metabolic and mental health conditions, and various conditions whose prevalence increases with aging.

Recent areas of interest concern the role of probiotics in mitigating the effects of reactive oxygen species, the metabolism of human milk oligosaccharides (HMO) in infants, and the production of a range of microbial metabolites such as short-chain fatty acids (SCFA).  

Selected Publications

  1. Labarre, A., Guitard, E., Tossing, G., & Parker, J. A. (2025). Suppression of har-1/CHCHD10 phenotypes for ALS-FTD therapy discovery. MicroPublication Biology, 2025. https://doi.org/10.17912/micropub.biology.001598
  2. Zhang, M., Ding, L., Strodl, E., Yin, X., Wen, G., Sun, D., Xian, D., Zhao, Y., Zheng, Y., Liu, F., Hu, R., Zhao, L., Yang, W., & Chen, W. (2025). Early supplement of probiotics reduces the risk of obesity among preschool children: A real-world observational study. Frontiers in Nutrition, 12, 1597894. https://doi.org/10.3389/fnut.2025.1597894  
  3. Barry, D. J., Farragher, J. B., Betik, A. C., Fyfe, J. J., Convit, L., & Cooke, M. B. (2024). Investigating the effects of synbiotic supplementation on functional movement, strength and muscle health in older Australians: A study protocol for a double-blind, randomized, placebo-controlled trial. Trials, 25(1). https://doi.org/10.1186/s13063-024-08130-9  
  4. Faramia, J., Choi, B. S.-Y., Brunelle, L., Marette, A., Drapeau, V., Tremblay, A., & Picard, F. (2024). Effects of Lacticaseibacillus rhamnosus HA-114 probiotic supplementation on circulating IGFBP-2 levels during a calorie-restricted diet in overweight humans. Journal of Clinical & Translational Endocrinology, 100357. https://doi.org/10.1016/j.jcte.2024.100357 
  5. Foster, S. G., Mathew, S., Labarre, A., Parker, J. A., Tompkins, T. A., & Binda, S. (2024). Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 Prolong Lifespan and Mitigate Amyloid-β Toxicity in C. elegans via Distinct Mechanisms. Journal of Alzheimer’s Disease, 101(1), 49-60. https://doi.org/10.3233/jad-230948  
  6. Guo, C., He, S., Le Barz, M., Binda, S., & Wang, H. (2024). A mix of probiotic strains prevents hepatic steatosis, and improves oxidative stress status and gut microbiota composition in obese mice. Molecular Nutrition & Food Research, 68, 2300672. https://doi.org/10.1002/mnfr.202300672 
  7. Noori, M., Shateri, Z., Babajafari, S., Eskandari, M. H., Parastouei, K., Ghasemi, M., Afshari, H., & Samadi, M. (2024). The effect of probiotic-fortified kefir on cardiovascular risk factors in elderly population: A double-blind, randomized, placebo-controlled clinical trial. BMC Nutrition, 10(1), 74. https://doi.org/10.1186/s40795-024-00875-5 
  8. Choi, B. S.-Y., et al. (2023). Lacticaseibacillus rhamnosus HA-114 improves eating behaviors and mood-related factors in adults with overweight during weight loss: A randomized controlled trial. Nutritional Neuroscience, 26(7), 667-679. https://doi.org/10.1080/1028415X.2022.2081288 
  9. Huang, J., Xu, Y., Wang, M., Yu, S., Li, Y., Tian, H., Zhang, C., & Li, H. (2023). Enterococcus faecium R-026 combined with Bacillus subtilis R-179 alleviate hypercholesterolemia and modulate the gut microbiota in C57BL/6 mice. FEMS Microbiology Letters, 370, 1-10. https://doi.org/10.1093/femsle/fnad118  
  10. Myles, E. M., Hamm, S. I., Allden, S. N., Romkey, I. D., O’Leary, M. E., & Perrot, T. S. (2023). A comparative study of Western, high-carbohydrate, and standard lab diet consumption throughout adolescence on metabolic and anxiety-related outcomes in young adult male and female Long-Evans rats. Behavioural Brain Research, 438, 114184. https://doi.org/10.1016/j.bbr.2022.114184 
  11. Kim, G., Yoon, Y., Park, J. H., Park, J. W., Noh, M.-g., Kim, H., Park, C., Kwon, H., Park, J.-h., Kim, Y., Sohn, J., Park, S., Kim, H., Im, S.-K., Kim, Y., Chung, H. Y., Nam, M. H., Kwon, J. Y., Kim, I. Y.,…Seong, J. K. (2022). Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity. Microbiome, 10(1), 188. https://doi.org/10.1186/s40168-022-01374-0
  12. Labarre, A., Guitard, E., Tossing, G., Forest, A., Bareke, E., Labrecque, M., Tétreault, M., Ruiz, M., & Parker, J. A. (2022). Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration. Communications Biology, 5(1), 1340. https://doi.org/10.1038/s42003-022-04295-8 
  13. Huang, J., Huang, J., Yin, T., Lv, H., Zhang, P., & Li, H. (2021). Enterococcus faecium R0026 combined with Bacillus subtilis R0179 prevent obesity-associated hyperlipidemia and modulate gut microbiota in C57BL/6 mice. Journal of Microbiology and Biotechnology, 31(2), 181-188. https://doi.org/10.4014/jmb.2009.09005  
  14. Walsh, C., Lane, J. A., Van Sinderen, D., & Hickey, R. M. (2022). Human milk oligosaccharide-sharing by a consortium of infant derived Bifidobacterium species. Scientific Reports, 12(1), 4143. https://doi.org/10.1038/s41598-022-07904-y  
  15. Gaisawat, M. B., Iskandar, M. M., MacPherson, C. W., Tompkins, T. A., & Kubow, S. (2019). Probiotic supplementation is associated with increased antioxidant capacity and copper chelation in C. difficile-infected fecal water. Nutrients, 11(9), 2007. https://doi.org/10.3390/nu11092007  
  16. Gaisawat, M. B., Macpherson, C. W., Tremblay, J., Piano, A., Iskandar, M. M., Tompkins, T. A., & Kubow, S. (2019). Probiotic supplementation in a Clostridium difficile-infected gastrointestinal model is associated with restoring metabolic function of microbiota. Microorganisms, 8(1), 60. https://doi.org/10.3390/microorganisms8010060  
  17. Wang, Q., Lv, L., Jiang, H., Wang, K., Yan, R., Li, Y., Ye, J., Wu, J., Wang, Q., Bian, X., Yang, L., Jiang, X., Xie, J., Lu, Y., Shen, J., & Li, L. (2019). Lactobacillus helveticus R0052 alleviates liver injury by modulating gut microbiome and metabolome in d-galactosamine-treated rats. Applied Microbiology and Biotechnology, 103(23), 9673-9686. https://doi.org/10.1007/s00253-019-10211-8 
  18. Xiao, L., Gong, C., Ding, Y., Ding, G., Xu, X., Deng, C., Ze, X., Malard, P., & Ben, X. (2019). Probiotics maintain intestinal secretory immunoglobulin A levels in healthy formula-fed infants: a randomised, double-blind, placebo-controlled study. Beneficial Microbes, 10(7), 729-740. https://doi.org/10.3920/bm2019.0025 
  19. De Andrés, J., Manzano, S., García, C., Rodríguez, J., Espinosa-Martos, I., & Jiménez, E. (2018). Modulatory effect of three probiotic strains on infants’ gut microbial composition and immunological parameters on a placebo-controlled, double-blind, randomised study. Beneficial Microbes, 9(4), 573-584. https://doi.org/10.3920/BM2017.0132 
  20. Cakir, M., Isbilen, A., Eyupoglu, I., Sag, E., Örem, A., Sen, T., Kaklikkaya, N., & Kaya, G. (2017). Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease. Turkish Journal of Gastroenterology, 28(5), 377-383. https://doi.org/10.5152/tjg.2017.17084  
  21. Manzano, S., De Andrés, J., Castro, I., Rodríguez, J., Jiménez, E., & Espinosa-Martos, I. (2017). Safety and tolerance of three probiotic strains in healthy infants: A multi-centre randomized, double-blind, placebo-controlled trial. Beneficial Microbes, 8(4), 569-578. https://doi.org/10.3920/BM2017.0009 
  22. Michalickova, D., Kotur-Stevuljevic, J., Miljkovic, M., Dikic, N., Kostic-Vucicevic, M., Andjelkovic, M., Koricanac, V., & Djordjevic, B. (2018). Effects of probiotic supplementation on selected parameters of blood prooxidant-antioxidant balance in elite athletes: A double-blind randomized placebo-controlled study. Journal of Human Kinetics, 64, 111-122. https://doi.org/10.1515/hukin-2017-0203 
  23. Michalickova, D. M., Kostic-Vucicevic, M. M., Vukasinovic-Vesic, M. D., Stojmenovic, T. B., Dikic, N. V., Andjelkovic, M. S., Djordjevic, B. I., Tanaskovic, B. P., & Minic, R. D. (2017). Lactobacillus helveticus Lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial. The Journal of Strength & Conditioning Research, 31(1), 62-70. https://doi.org/10.1519/JSC.0000000000001456 
  24. Michalickova, D., Minic, R., Dikic, N., Andjelkovic, M., Kostic-Vucicevic, M., Stojmenovic, T., Nikolic, I., & Djordjevic, B. (2016). Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: A randomized, double-blind, placebo-controlled trial. Applied Physiology, Nutrition, and Metabolism, 41(7), 782-789. https://doi.org/10.1139/apnm-2015-0541 
  25. Clancy, R. L., Gleeson, M., Cox, A., Callister, R., Dorrington, M., D’Este, C., Pang, G., Pyne, D., Fricker, P., & Henriksson, A. (2006). Reversal in fatigued athletes of a defect in interferon γ secretion after administration of Lactobacillus acidophilus. British Journal of Sports Medicine, 40(4), 351-354. https://doi.org/10.1136/bjsm.2005.024364 

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